Thrust 1 — Imaging Biomarkers
Automated DaT-SPECT and T1 MRI pipelines generate harmonized biomarker matrices that sharpen CSFSAA stratification and feed downstream agents.
Domain Thrusts
Four coordinated thrusts extract, harmonize, and interpret multimodal biomarkers. Each thrust tackles a distinct modality -- imaging, diffusion-clinical integration, wearable-cognitive phenotyping, and mechanistic inference -- while sharing common quality controls and translational goals.
Dive into the thrusts below for deeper technical walkthroughs, figures, and validated findings.
Explore the thrusts
Thrust 2 — Diffusion + Clinical Co-Clustering
Free-water–corrected diffusion metrics align with clinical scales inside a compositional Bayesian co-clustering framework, revealing severity-aligned patient subtypes.
Thrust 3 — Wearable & Cognitive Phenotyping
Wearable IMU data, cognitive batteries, and demographics combine to predict CSFSAA status and uncover multimodal phenotypes.
Thrust 4 — Mechanism Inference
Large-scale statistical testing links multimodal biomarkers to putative biological pathways, grounding discoveries in mechanism-centric hypotheses.