Biomedical appendix
PPMI co-clustering as a Parkinson's exploration
The paper appendix applies the co-clustering approach to PPMI clinical and imaging variables. This section is exploratory and should be read as biomarker-discovery analysis, not diagnostic deployment.
Mild outlier profile
One near-singleton group shows low motor burden, high MoCA, early Hoehn and Yahr stage, and mild or near-normal imaging values.
Older heterogeneous group
An older cluster displays wider motor severity and comparatively preserved DaTSCAN signals, suggesting non-linear relationships among age, imaging, and symptoms.
Moderate PD subgroups
Several broader groups share moderate severity but differ by cognition, imaging spread, age at diagnosis, and ventricular or striatal measures.
Candidate biomarker families
Putamen and caudate DaTSCAN ratios, ventricular and striatal MRI volumes, UPDRS-III, Hoehn and Yahr stage, and MoCA emerge as separating variables.