CVC Seminar: Wed Apr 13 1:30-3pm ACES 4.304

Md Muhibur Rasheed

Multi protein docking

More than 80% of the proteins in living cells are found either as symmetric oligomers formed by copies of same protein, or as heterogeneous complexes with other proteins. More than half of these complexes consist of more than 2 proteins and hence predicting such complex/assembly falls beyond the scope of traditional pairwise docking techniques. The goal of this talk is to review the current state of the art in multi protein docking and to identify unsolved problems. We shall discuss, compare and critique the existing multi-protein docking algorithms. For each of these algorithms we identify the classes of oligomers that can be predicted by the algorithm, the underlying docking principle, how the algorithm deals with the combinatorics of the multi-protein complex, and how the method was tested/validated.